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Comparative Effect of 1.2% Atorvastatin Gel And 1.2% Rosuvastatin as a Local Drug Delivery in Treatment of Intra-Bony Defects in Chronic Periodontitis

Background: The present study was aimed to evaluate the efficacy of 1.2% Atorvastatin with that of 1.2% Rosuvastatin as local drug delivery the treatment of chronic periodontitis.

Method and Material: 40 Patients were equally divided in 2 groups. Group A underwent scaling and root debridement and 1.2% Atorvastatin (ASV) gel (1.2 mg/0.1 mL) whereas group B received scaling and root debridement and Rosuvastatin (RSV) (1.2 mg/0.1 mL) g.

Results: The results showed that both the group showed improvement in all the recorded parameters and the results obtained were statistically significant. When comparison was made between the groups no significant difference was obtained between atorvastatin and Rovustatin at baseline in all recorded parameters. However after six months significant improvement was recorded in CAL and PD. The plaque and gingival index score however showed improvement but it did not attain level of significance.

Conclusion: The present study shows improvement in clinical parameters with the use of ATV and ASV gel when used in combination with SRP in Chronic Periodontitis patients. Patients with RSV gel showed significantly better than the ones in which ATV gel was placed.


Ashish Soni, Swati Raj, Laxmikant Kashyap, Amit Upadhyay, Vikas Agrihari, Anil Sharma, Anil Agrawal*

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